Interaction of resting-state networks and their relation to auditory verbal hallucinations
The theoretical framework of this project is that auditory verbal hallucinations (AVH) result from intrinsic, functional interactions within a widespread brain network that consists primarily of the auditory cortices (i.e., superior temporal gyrus/STG), medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and dorsolateral prefrontal cortex (DLPFC). While MPFC and PCC are the core medial hubs of the default mode network (DMN), the DLPFC is the main hub of the central executive network (CEN). Functional connectivity analyses provided evidence that the MPFC and the PCC are highly temporally correlated during rest, while the DMN is anticorrelated with brain regions of the CEN, which is activated during cognitively demanding tasks. Abnormalities of the DMN have consistently been associated with schizophrenia. Specifically, AVH have been linked to aberrant DMN-CEN interaction, to within MPFC-PCC hyperconnectivity and MPFC-STG hyperconnectivity. In this project, we investigate EEG resting-state data of patients with schizophrenia and a borderline personality disorder who do or do not have AVH. Our aims are (1) to identify frequency-specific network dynamics between and within DMN, CEN and STGs related to the emergence of AVH, and (2) to examine core features of AVH psychopathology that may cut across traditional diagnostic boundaries. The team includes Magali Madkaud and is in collaboration with Clemens Bauer (NUBIC), Susan Whitfield-Gabrieli (NUBIC), and Margaret Niznikiewicz (Harvard Medical School).